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pentobarbital will decrease the level or result of larotrectinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or effect of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to the de